Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase
2018-01-01 Pein, H.; Ville, A.; Pace, S.; Temml, V.; Garscha, U.; Raasch, M.; Alsabil, K.; Viault, G.; Dinh, C. -P.; Guilet, D.; Troisi, F.; Neukirch, K.; Konig, S.; Bilancia, R.; Waltenberger, B.; Stuppner, H.; Wallert, M.; Lorkowski, S.; Weinigel, C.; Rummler, S.; Birringer, M.; Roviezzo, F.; Sautebin, L.; Helesbeux, J. -J.; Seraphin, D.; Mosig, A. S.; Schuster, D.; Rossi, A.; Richomme, P.; Werz, O.; Koeberle, A.
BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly
2016-01-01 Garscha, U.; Voelker, S.; Pace, S.; Gerstmeier, J.; Emini, B.; Liening, S.; Rossi, A.; Weinigel, C.; Rummler, S.; Schubert, U. S.; Scriba, G. K. E.; Celikoglu, E.; Caliskan, B.; Banoglu, E.; Sautebin, L.; Werz, O.
The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP)
2014-01-01 Pergola, C.; Gerstmeier, J.; Monch, B.; Caliskan, B.; Luderer, S.; Weinigel, C.; Barz, D.; Maczewsky, J.; Pace, S.; Rossi, A.; Sautebin, L.; Banoglu, E.; Werz, O.
Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation
2018-01-01 Cheung, S. -Y.; Werner, M.; Esposito, L.; Troisi, F.; Cantone, V.; Liening, S.; Konig, S.; Gerstmeier, J.; Koeberle, A.; Bilancia, R.; Rizza, R.; Rossi, A.; Roviezzo, F.; Temml, V.; Schuster, D.; Stuppner, H.; Schubert-Zsilavecz, M.; Werz, O.; Hanke, T.; Pace, S.
Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction
2020-01-01 Gebert, N.; Cheng, C. -W.; Kirkpatrick, J. M.; Di Fraia, D.; Yun, J.; Schadel, P.; Pace, S.; Garside, G. B.; Werz, O.; Rudolph, K. L.; Jasper, H.; Yilmaz, O. H.; Ori, A.
Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males
2017-01-01 Pace, S.; Pergola, C.; Dehm, F.; Rossi, A.; Gerstmeier, J.; Troisi, F.; Pein, H.; Schaible, A. M.; Weinigel, C.; Rummler, S.; Northoff, H.; Laufer, S.; Maier, T. J.; Radmark, O.; Samuelsson, B.; Koeberle, A.; Sautebin, L.; Werz, O.
Bioactivity and Mode of Action of Bacterial Tetramic Acids
2019-01-01 Klapper, M.; Paschold, A.; Zhang, S.; Weigel, C.; Dahse, H. -M.; Gotze, S.; Pace, S.; Konig, S.; Rao, Z.; Reimer, L.; Werz, O.; Stallforth, P.
Use of Mometasone furoate in prolonged treatment of experimental spinal cord injury in mice: A comparative study of three different glucocorticoids
2015-01-01 Galuppo, M.; Rossi, A.; Giacoppo, S.; Pace, S.; Bramanti, P.; Sautebin, L.; Mazzon, E.
Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity
2016-01-01 Di Capua, A.; Sticozzi, C.; Brogi, S.; Brindisi, M.; Cappelli, A.; Sautebin, L.; Rossi, A.; Pace, S.; Ghelardini, C.; Di Cesare Mannelli, L.; Valacchi, G.; Giorgi, G.; Giordani, A.; Poce, G.; Biava, M.; Anzini, M.
The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects
2014-01-01 Romano, B.; Fasolino, I.; Pagano, E.; Capasso, R.; Pace, S.; De Rosa, G.; Milic, N.; Orlando, P.; Izzo, A. A.; Borrelli, F.
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity
2013-01-01 Battilocchio, C.; Poce, G.; Alfonso, S.; Porretta, G. C.; Consalvi, S.; Sautebin, L.; Pace, S.; Rossi, A.; Ghelardini, C.; Di Cesare Mannelli, L.; Schenone, S.; Giordani, A.; Di Francesco, L.; Patrignani, P.; Biava, M.
Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv. "cascade")
2016-01-01 Forino, M.; Pace, S.; Chianese, G.; Santagostini, L.; Werner, M.; Weinigel, C.; Rummler, S.; Fico, G.; Werz, O.; Taglialatela-Scafati, O.
Communication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesis
2020-01-01 Werner, M.; Pace, S.; Czapka, A.; Jordan, P. M.; Gerstmeier, J.; Koeberle, A.; Werz, O.
Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase
2017-01-01 Garscha, U.; Romp, E.; Pace, S.; Rossi, A.; Temml, V.; Schuster, D.; Konig, S.; Gerstmeier, J.; Liening, S.; Werner, M.; Atze, H.; Wittmann, S.; Weinigel, C.; Rummler, S.; Scriba, G. K.; Sautebin, L.; Werz, O.
SAR studies on curcumin's pro-inflammatory targets: Discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase
2014-01-01 Koeberle, A.; Munoz, E.; Appendino, G. B.; Minassi, A.; Pace, S.; Rossi, A.; Weinigel, C.; Barz, D.; Sautebin, L.; Caprioglio, D.; Collado, J. A.; Werz, O.
Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors
2019-01-01 Boccellino, M.; Donniacuo, M.; Bruno, F.; Rinaldi, B.; Quagliuolo, L.; Ambruosi, M.; Pace, S.; De Rosa, M.; Olgac, A.; Banoglu, E.; Alessio, N.; Massa, A.; Kahn, H.; Werz, O.; Fiorentino, A.; Filosa, R.
Vacuolar (H+)-ATPase critically regulates specialized proresolving mediator pathways in human M2-like monocyte-derived macrophages and has a crucial role in resolution of inflammation
2019-01-01 Rao, Z.; Pace, S.; Jordan, P. M.; Bilancia, R.; Troisi, F.; Borner, F.; Andreas, N.; Kamradt, T.; Menche, D.; Rossi, A.; Serhan, C. N.; Gerstmeier, J.; Werz, O.
Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors
2013-01-01 Anzini, M.; Di Capua, A.; Valenti, S.; Brogi, S.; Rovini, M.; Giuliani, G.; Cappelli, A.; Vomero, S.; Chiasserini, L.; Sega, A.; Poce, G.; Giorgi, G.; Calderone, V.; Martelli, A.; Testai, L.; Sautebin, L.; Rossi, A.; Pace, S.; Ghelardini, C.; Di Cesare Mannelli, L.; Benetti, V.; Giordani, A.; Anzellotti, P.; Dovizio, M.; Patrignani, P.; Biava, M.
The standardized herbal combination BNO 2103 contained in Canephron® N alleviates inflammatory pain in experimental cystitis and prostatitis
2019-01-01 Nausch, B.; Pace, S.; Pein, H.; Koeberle, A.; Rossi, A.; Kunstle, G.; Werz, O.
Erratum: Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors (Journal of Medicinal Chemistry (2013) 56 (3191-3206) DOI: 10.1021/jm301370e)
2013-01-01 Anzini, M.; Di Capua, A.; Valenti, S.; Brogi, S.; Rovini, M.; Giuliani, G.; Cappelli, A.; Vomero, S.; Chiasserini, L.; Sega, A.; Poce, G.; Giorgi, G.; Calderone, V.; Martelli, A.; Testai, L.; Sautebin, L.; Rossi, A.; Pace, S.; Ghelardini, C.; Di Cesare Mannelli, L.; Benetti, V.; Giordani, A.; Anzellotti, P.; Dovizio, M.; Patrignani, P.; Biava, M.
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase | 1-gen-2018 | Pein, H.; Ville, A.; Pace, S.; Temml, V.; Garscha, U.; Raasch, M.; Alsabil, K.; Viault, G.; Dinh, C. -P.; Guilet, D.; Troisi, F.; Neukirch, K.; Konig, S.; Bilancia, R.; Waltenberger, B.; Stuppner, H.; Wallert, M.; Lorkowski, S.; Weinigel, C.; Rummler, S.; Birringer, M.; Roviezzo, F.; Sautebin, L.; Helesbeux, J. -J.; Seraphin, D.; Mosig, A. S.; Schuster, D.; Rossi, A.; Richomme, P.; Werz, O.; Koeberle, A. | |
| BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly | 1-gen-2016 | Garscha, U.; Voelker, S.; Pace, S.; Gerstmeier, J.; Emini, B.; Liening, S.; Rossi, A.; Weinigel, C.; Rummler, S.; Schubert, U. S.; Scriba, G. K. E.; Celikoglu, E.; Caliskan, B.; Banoglu, E.; Sautebin, L.; Werz, O. | |
| The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP) | 1-gen-2014 | Pergola, C.; Gerstmeier, J.; Monch, B.; Caliskan, B.; Luderer, S.; Weinigel, C.; Barz, D.; Maczewsky, J.; Pace, S.; Rossi, A.; Sautebin, L.; Banoglu, E.; Werz, O. | |
| Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation | 1-gen-2018 | Cheung, S. -Y.; Werner, M.; Esposito, L.; Troisi, F.; Cantone, V.; Liening, S.; Konig, S.; Gerstmeier, J.; Koeberle, A.; Bilancia, R.; Rizza, R.; Rossi, A.; Roviezzo, F.; Temml, V.; Schuster, D.; Stuppner, H.; Schubert-Zsilavecz, M.; Werz, O.; Hanke, T.; Pace, S. | |
| Region-Specific Proteome Changes of the Intestinal Epithelium during Aging and Dietary Restriction | 1-gen-2020 | Gebert, N.; Cheng, C. -W.; Kirkpatrick, J. M.; Di Fraia, D.; Yun, J.; Schadel, P.; Pace, S.; Garside, G. B.; Werz, O.; Rudolph, K. L.; Jasper, H.; Yilmaz, O. H.; Ori, A. | |
| Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males | 1-gen-2017 | Pace, S.; Pergola, C.; Dehm, F.; Rossi, A.; Gerstmeier, J.; Troisi, F.; Pein, H.; Schaible, A. M.; Weinigel, C.; Rummler, S.; Northoff, H.; Laufer, S.; Maier, T. J.; Radmark, O.; Samuelsson, B.; Koeberle, A.; Sautebin, L.; Werz, O. | |
| Bioactivity and Mode of Action of Bacterial Tetramic Acids | 1-gen-2019 | Klapper, M.; Paschold, A.; Zhang, S.; Weigel, C.; Dahse, H. -M.; Gotze, S.; Pace, S.; Konig, S.; Rao, Z.; Reimer, L.; Werz, O.; Stallforth, P. | |
| Use of Mometasone furoate in prolonged treatment of experimental spinal cord injury in mice: A comparative study of three different glucocorticoids | 1-gen-2015 | Galuppo, M.; Rossi, A.; Giacoppo, S.; Pace, S.; Bramanti, P.; Sautebin, L.; Mazzon, E. | |
| Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity | 1-gen-2016 | Di Capua, A.; Sticozzi, C.; Brogi, S.; Brindisi, M.; Cappelli, A.; Sautebin, L.; Rossi, A.; Pace, S.; Ghelardini, C.; Di Cesare Mannelli, L.; Valacchi, G.; Giorgi, G.; Giordani, A.; Poce, G.; Biava, M.; Anzini, M. | |
| The chemopreventive action of bromelain, from pineapple stem (Ananas comosus L.), on colon carcinogenesis is related to antiproliferative and proapoptotic effects | 1-gen-2014 | Romano, B.; Fasolino, I.; Pagano, E.; Capasso, R.; Pace, S.; De Rosa, G.; Milic, N.; Orlando, P.; Izzo, A. A.; Borrelli, F. | |
| A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity | 1-gen-2013 | Battilocchio, C.; Poce, G.; Alfonso, S.; Porretta, G. C.; Consalvi, S.; Sautebin, L.; Pace, S.; Rossi, A.; Ghelardini, C.; Di Cesare Mannelli, L.; Schenone, S.; Giordani, A.; Di Francesco, L.; Patrignani, P.; Biava, M. | |
| Humudifucol and Bioactive Prenylated Polyphenols from Hops (Humulus lupulus cv. "cascade") | 1-gen-2016 | Forino, M.; Pace, S.; Chianese, G.; Santagostini, L.; Werner, M.; Weinigel, C.; Rummler, S.; Fico, G.; Werz, O.; Taglialatela-Scafati, O. | |
| Communication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesis | 1-gen-2020 | Werner, M.; Pace, S.; Czapka, A.; Jordan, P. M.; Gerstmeier, J.; Koeberle, A.; Werz, O. | |
| Pharmacological profile and efficiency in vivo of diflapolin, the first dual inhibitor of 5-lipoxygenase-activating protein and soluble epoxide hydrolase | 1-gen-2017 | Garscha, U.; Romp, E.; Pace, S.; Rossi, A.; Temml, V.; Schuster, D.; Konig, S.; Gerstmeier, J.; Liening, S.; Werner, M.; Atze, H.; Wittmann, S.; Weinigel, C.; Rummler, S.; Scriba, G. K.; Sautebin, L.; Werz, O. | |
| SAR studies on curcumin's pro-inflammatory targets: Discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase | 1-gen-2014 | Koeberle, A.; Munoz, E.; Appendino, G. B.; Minassi, A.; Pace, S.; Rossi, A.; Weinigel, C.; Barz, D.; Sautebin, L.; Caprioglio, D.; Collado, J. A.; Werz, O. | |
| Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors | 1-gen-2019 | Boccellino, M.; Donniacuo, M.; Bruno, F.; Rinaldi, B.; Quagliuolo, L.; Ambruosi, M.; Pace, S.; De Rosa, M.; Olgac, A.; Banoglu, E.; Alessio, N.; Massa, A.; Kahn, H.; Werz, O.; Fiorentino, A.; Filosa, R. | |
| Vacuolar (H+)-ATPase critically regulates specialized proresolving mediator pathways in human M2-like monocyte-derived macrophages and has a crucial role in resolution of inflammation | 1-gen-2019 | Rao, Z.; Pace, S.; Jordan, P. M.; Bilancia, R.; Troisi, F.; Borner, F.; Andreas, N.; Kamradt, T.; Menche, D.; Rossi, A.; Serhan, C. N.; Gerstmeier, J.; Werz, O. | |
| Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors | 1-gen-2013 | Anzini, M.; Di Capua, A.; Valenti, S.; Brogi, S.; Rovini, M.; Giuliani, G.; Cappelli, A.; Vomero, S.; Chiasserini, L.; Sega, A.; Poce, G.; Giorgi, G.; Calderone, V.; Martelli, A.; Testai, L.; Sautebin, L.; Rossi, A.; Pace, S.; Ghelardini, C.; Di Cesare Mannelli, L.; Benetti, V.; Giordani, A.; Anzellotti, P.; Dovizio, M.; Patrignani, P.; Biava, M. | |
| The standardized herbal combination BNO 2103 contained in Canephron® N alleviates inflammatory pain in experimental cystitis and prostatitis | 1-gen-2019 | Nausch, B.; Pace, S.; Pein, H.; Koeberle, A.; Rossi, A.; Kunstle, G.; Werz, O. | |
| Erratum: Novel analgesic/anti-inflammatory agents: 1,5-Diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors (Journal of Medicinal Chemistry (2013) 56 (3191-3206) DOI: 10.1021/jm301370e) | 1-gen-2013 | Anzini, M.; Di Capua, A.; Valenti, S.; Brogi, S.; Rovini, M.; Giuliani, G.; Cappelli, A.; Vomero, S.; Chiasserini, L.; Sega, A.; Poce, G.; Giorgi, G.; Calderone, V.; Martelli, A.; Testai, L.; Sautebin, L.; Rossi, A.; Pace, S.; Ghelardini, C.; Di Cesare Mannelli, L.; Benetti, V.; Giordani, A.; Anzellotti, P.; Dovizio, M.; Patrignani, P.; Biava, M. |
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