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Advances in Oncologic Therapies During Pregnancy: Balancing Maternal Cure With Fetal Safety in Reproductive Cancers

Gynecologic cancer during pregnancy requires treatment decisions that preserve maternal oncologic efficacy while minimizing fetal harm. This focused narrative review critically evaluates systemic therapy for cervical, ovarian, and other selected gynecologic malignancies during pregnancy, with surgery, radiotherapy, obstetric outcomes, and emerging technologies discussed only when they directly inform systemic-treatment decisions. Evidence is interpreted using a transparent four-category frame...

Baroreflex control of heart rate at rest and during exercise in microgravity conditions

: One of the most important features of prolonged weightlessness is a progressive impairment of muscular function. Physiological modifications related to exposure to microgravity, e.g. altered blood volume distribution, impaired myocardial function, and a decrease in stroke volume, in addition to the alterations in muscular function, contribute to the reduced physical exercise capacity commonly reported after space flight. The interplay between muscular, hemodynamic and body fluid modificatio...

Antiplasmodial activities of gold(I) complexes involving functionalized N-heterocyclic carbenes

A series of twenty five molecules, including imidazolium salts functionalized by N-, O- or S-containing groups and their corresponding cationic, neutral or anionic gold(I) complexes were evaluated on Plasmodium falciparum in vitro and then on Vero cells to determine their selectivity. Among them, eight new compounds were synthesized and fully characterized by spectroscopic methods. The X-ray structures of three gold(I) complexes are presented. Except one complex (18), all the cationic gold(I)...

Unusual zymogen activation patterns in the protein corona of Ca-zeolites

Zymogen (prothrombin) activation is central to the process of haemostasis (blood clotting) in the body, preventing serious blood loss and death from haemorrhagic shock. Zeolites comprise a family of crystalline microporous aluminosilicates that show increasing promise for use in massive bleeding control. However, the mechanism of zeolite-initiated haemostasis has remained unclear. Here, we investigate zeolite-initiated thrombin activation at the molecular level, and show that a prothrombinase...

Biological recognition of graphene nanoflakes

The systematic study of nanoparticle-biological interactions requires particles to be reproducibly dispersed in relevant fluids along with further development in the identification of biologically relevant structural details at the materials-biology interface. Here, we develop a biocompatible long-Term colloidally stable water dispersion of few-layered graphene nanoflakes in the biological exposure medium in which it will be studied. We also report the study of the orientation and functionali...

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