IRISanRaf

Oral Health and Nutraceutical Agents

: Oral health is essential for both overall health and quality of life. The mouth is a window into the body's health, and nutrition can strongly impact the state of general and oral health. A healthy diet involves the synergistic effect of various nutraceutical agents, potentially capable of conferring protective actions against some inflammatory and chronic-degenerative disorders. Nutraceuticals, mostly present in plant-derived products, present multiple potential clinical, preventive, and t...

Establishment of a Biorepository for Down Syndrome: Experience of the Inter-Institutional Multidisciplinary BioBank - BioBIM

Background: Down syndrome, or Trisomy 21, is the leading genetic cause of cognitive disability in children and is associated with a high risk of several comorbidities, particularly congenital heart defects, early onset Alzheimer's disease, leukaemia, and autoimmune disorders. Objective: This study describes the design, methods, and operational procedures employed to establish a biobank dedicated to Down syndrome that can support research projects investigating the effects of various genetic a...

HSV-1 infection induces phosphorylated tau propagation among neurons via extracellular vesicles

Extracellular vesicles (EV), key players in cell-to-cell communication, maycontribute to disease propagation in several neurodegenerative diseases, includingAlzheimer’s disease (AD), by favoring the dissemination of neurotoxic proteins withinthe brain. Interestingly, growing evidence supports the role of herpes simplex virus type1 (HSV-1) infection in the pathogenesis of AD. Here, we investigated whether HSV-1infection could promote the spread of phosphorylated tau (ptau) among neurons viaEV....

Acinetobacter baumannii OmpA-like porins: functional characterization of bacterial physiology, antibiotic-resistance, and virulence