König et al. identified leukotriene A 4 hydrolase (LTA 4 H) in human leukocytes as a molecular target of gliotoxin from Aspergillus fumigatus. Under reducing conditions, gliotoxin inhibits leukotriene A 4 hydrolase activity leading to suppression of chemotactic leukotriene B 4 biosynthesis and neutrophil infiltration, which may underlie the neutrophil-compromising properties of this fungal toxin.
Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B 4 Formation through Inhibition of Leukotriene A 4 Hydrolase
Pace S.;
2019-01-01
Abstract
König et al. identified leukotriene A 4 hydrolase (LTA 4 H) in human leukocytes as a molecular target of gliotoxin from Aspergillus fumigatus. Under reducing conditions, gliotoxin inhibits leukotriene A 4 hydrolase activity leading to suppression of chemotactic leukotriene B 4 biosynthesis and neutrophil infiltration, which may underlie the neutrophil-compromising properties of this fungal toxin.File in questo prodotto:
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