Epigenetic aberrations caused by environmental factors and lifestyle choices have been associated with the development of a number of pathologies, including cardiovascular disorders. However, whether obesity-related heart dysfunction can occur via epigenetic mechanisms is largely undisclosed. The manifested role of DNA hydroxymethylation in heart pathophysiology prompts an investigation of its levels/machinery in heart of mice fed with high-fat diet (HFD) and its possible relation with genes linked to obesity-associated cardiac remodeling.

High Dietary Fat Intake Affects DNA Methylation/Hydroxymethylation in Mouse Heart: Epigenetic Hints for Obesity-Related Cardiac Dysfunction

Ciccarone, Fabio;
2019-01-01

Abstract

Epigenetic aberrations caused by environmental factors and lifestyle choices have been associated with the development of a number of pathologies, including cardiovascular disorders. However, whether obesity-related heart dysfunction can occur via epigenetic mechanisms is largely undisclosed. The manifested role of DNA hydroxymethylation in heart pathophysiology prompts an investigation of its levels/machinery in heart of mice fed with high-fat diet (HFD) and its possible relation with genes linked to obesity-associated cardiac remodeling.
2019
5-formylcytosine; TET enzymes; epigenetics; heart hypertrophy; high-fat diet; Animals; Cardiomegaly; Cytoskeletal Proteins; DNA Methylation; DNA-Binding Proteins; Diet, High-Fat; Dietary Fats; Enzymes; Epigenesis, Genetic; Gene Expression Regulation; Heart; LIM Domain Proteins; Male; Mice, Inbred C57BL; Mitochondria, Heart; Nuclear Proteins; Obesity; Protein Carbonylation
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12078/4584
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