A stereocontrolled synthesis of (2S,3R)-3-hydroxyproline 1, and trans-(2R,3S)--2-hydroxymethyl-3-hydroxypyrrolidine 2 has been achieved in 21% and 38% yield via the homochiral 4,5-disubstituted oxazolidin-2-one 3. The trans relationship in 2 has beenintroduced by a modified Mitsunobu reaction.

A straightforward synthesis of (2S,3R)-3-hydroxyproline and trans-(2R,3S)-2- hydroxymethyl-3-hydroxypyrrolidine

ZAPPIA, GIOVANNI;
1996-01-01

Abstract

A stereocontrolled synthesis of (2S,3R)-3-hydroxyproline 1, and trans-(2R,3S)--2-hydroxymethyl-3-hydroxypyrrolidine 2 has been achieved in 21% and 38% yield via the homochiral 4,5-disubstituted oxazolidin-2-one 3. The trans relationship in 2 has beenintroduced by a modified Mitsunobu reaction.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12078/19567
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