Control of biospecimen quality that is linked to processing is one of the goals of biospecimen science. Consensus is tacking, however, regarding optimal sample quality-control (QC) tools (ie, markers and assays). The aim of this review was to identify QC tools, both for fluid and solid-tissue samples, based on a comprehensive and critical literature review. The most readily applicable tools are those with a known threshold for the preanalytical variation and a known reference range for the QC analyte. Only a few meaningful markers were identified that meet these criteria, such as CD40L for assessing serum exposure at high temperatures and VEGF for assessing serum freeze-thawing. To fully assess biospecimen quality, multiple QC markers are needed. Here we present the most promising biospecimen QC tools that were identified. (J Mal Diagn 2013, 15: 3-16; http://dx.doi.org/10.1016/j.jmoldx.2012.06.008)
Identification of Evidence-Based Biospecimen Quality-Control Tools A Report of the International Society for Biological and Environmental Repositories (ISBER) Biospecimen Science Working Group
Guadagni F;
2013-01-01
Abstract
Control of biospecimen quality that is linked to processing is one of the goals of biospecimen science. Consensus is tacking, however, regarding optimal sample quality-control (QC) tools (ie, markers and assays). The aim of this review was to identify QC tools, both for fluid and solid-tissue samples, based on a comprehensive and critical literature review. The most readily applicable tools are those with a known threshold for the preanalytical variation and a known reference range for the QC analyte. Only a few meaningful markers were identified that meet these criteria, such as CD40L for assessing serum exposure at high temperatures and VEGF for assessing serum freeze-thawing. To fully assess biospecimen quality, multiple QC markers are needed. Here we present the most promising biospecimen QC tools that were identified. (J Mal Diagn 2013, 15: 3-16; http://dx.doi.org/10.1016/j.jmoldx.2012.06.008)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
