Aim: This study was designed to assess the prognostic significance of the combined measurement of vascular endothelial growth factor ( VEGF) and carcinoembryonic antigen ( CEA) tissue content with respect to relapse- free and overall survival of patients with colorectal cancer ( CRC). Methods: Quantitative evaluation of VEGF and CEA content was performed on protein extracts obtained from tissue biopsies from 69 CRC patients and 15 healthy donors. Results: VEGF significantly correlated with CEA content of either tumor tissues ( rho = 0.55, p < 0.0001) or corresponding normal mucosa ( rho = 0.34, p < 0.005). General regression analyses demonstrated that CEA was an independent predictor of VEGF tissue content either in CRC biopsies ( regression coefficient = 0.57, p < 0.0001) or normal mucosa ( regression coefficient = 0.25, p < 0.05). Cox proportional hazards survival analysis showed that tumor tissue content of both VEGF and CEA had an independent prognostic value in predicting both relapse- free ( hazards ratio = 5.98, p = 0.002) and overall ( hazards ratio = 4.73, p = 0.007) survival, irrespective of Dukes' stage. Kaplan- Meier analysis demonstrated that anelevated tumor content of both CEA and VEGF had a negative prognostic value in respect to either relapse- free ( logrank test: 10.4, p = 0.001) or overall survival ( log- rank test: 7.33, p = 0.007). Conclusion: Tumor tissue VEGF and CEA content determination might add useful prognostic information in the management of patients with CRC.

Prognostic value of carcinoembryonic antigen and vascular endothelial growth factor tumor tissue content in colorectal cancer

Ferroni P;Guadagni F
2006-01-01

Abstract

Aim: This study was designed to assess the prognostic significance of the combined measurement of vascular endothelial growth factor ( VEGF) and carcinoembryonic antigen ( CEA) tissue content with respect to relapse- free and overall survival of patients with colorectal cancer ( CRC). Methods: Quantitative evaluation of VEGF and CEA content was performed on protein extracts obtained from tissue biopsies from 69 CRC patients and 15 healthy donors. Results: VEGF significantly correlated with CEA content of either tumor tissues ( rho = 0.55, p < 0.0001) or corresponding normal mucosa ( rho = 0.34, p < 0.005). General regression analyses demonstrated that CEA was an independent predictor of VEGF tissue content either in CRC biopsies ( regression coefficient = 0.57, p < 0.0001) or normal mucosa ( regression coefficient = 0.25, p < 0.05). Cox proportional hazards survival analysis showed that tumor tissue content of both VEGF and CEA had an independent prognostic value in predicting both relapse- free ( hazards ratio = 5.98, p = 0.002) and overall ( hazards ratio = 4.73, p = 0.007) survival, irrespective of Dukes' stage. Kaplan- Meier analysis demonstrated that anelevated tumor content of both CEA and VEGF had a negative prognostic value in respect to either relapse- free ( logrank test: 10.4, p = 0.001) or overall survival ( log- rank test: 7.33, p = 0.007). Conclusion: Tumor tissue VEGF and CEA content determination might add useful prognostic information in the management of patients with CRC.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12078/1908
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