The first example of the use of ammonia, the waste material of the bulk glycerol carbonate (GC) production, for the formation of another valuable organic molecule, a 1,4-dihydropyridine (1,4-DHP), by an in line two reactor system was presented. Two Q-tube reactors, one for the urea glycerolysis and the other for the Hantzsch reaction, were used, connected through a PTFE tube. Urea glycerolysis using La2O3 as heterogeneous catalyst, under N2 pressure or in vacuum conditions, was optimized. A catalyst free and organic solvent free condition was selected to realize a Hantzsch reaction in an ecofriendly way. Glycerol carbonate and a 1,4-dihydropyridine were synthesized in two subsequent reactions, converting wastes into added value products. The best result was that glycerol carbonate was obtained at 36% with 77% of selectivity, and at the same time the Hantzsch product was synthesized with a 75% of yield.

Multicomponent Reaction Exploiting Glycerol Carbonate Synthesis.

NARDI M;
2018

Abstract

The first example of the use of ammonia, the waste material of the bulk glycerol carbonate (GC) production, for the formation of another valuable organic molecule, a 1,4-dihydropyridine (1,4-DHP), by an in line two reactor system was presented. Two Q-tube reactors, one for the urea glycerolysis and the other for the Hantzsch reaction, were used, connected through a PTFE tube. Urea glycerolysis using La2O3 as heterogeneous catalyst, under N2 pressure or in vacuum conditions, was optimized. A catalyst free and organic solvent free condition was selected to realize a Hantzsch reaction in an ecofriendly way. Glycerol carbonate and a 1,4-dihydropyridine were synthesized in two subsequent reactions, converting wastes into added value products. The best result was that glycerol carbonate was obtained at 36% with 77% of selectivity, and at the same time the Hantzsch product was synthesized with a 75% of yield.
Ammonia recicle; Heterogeneous catalysis ; Multicomponent reactions
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/20.500.12078/1745
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