A simple procedure to obtain 1,5-disubstituted 1,2,3-triazoles, using the Er(OTf)3/[mpy]OTf/H2O catalytic system is described. The reaction proceeds through an eliminative azide–olefin cycloaddition (EAOC) offering a highly regioselective approach and good yields (81–94%). The advantages of this method include simple operations of work-up and the ability of the catalytic system to be re-used five times without an evident loss in yield. The role of IL and water were speculated, invoking also a probable ionic self-assembly (ISA) effect.
|Titolo:||Regioselective synthesis of 1,5-disubstituted 1,2,3 triazoles by 1,3-dipolar cycloaddition: Role of Er(OTf)3, ionic liquid and water|
|Data di pubblicazione:||2019|
|Appare nelle tipologie:||1.1 Articolo in rivista|