BackgroundDespite its negative impact on quality of life, fatigue in Parkinson's disease (PD) remains an under-recognized issue and the underlying pathology is undetermined.ObjectiveTo contribute at understanding the pathogenesis of fatigue in a naturalistic cohort of cognitively intact PD patients.MethodsIn a Caucasian population of PD patients (n=27), we evaluated to what extent fatigue (quantified as PFS-16 score) is associated with PD duration and with autonomic dysfunction, studied by both MIBG scintigraphy and autonomic nervous system testing. The latter included the head-up tilt test, Valsalva maneuver, deep breathing, and handgrip tests.ResultsPFS-16 score correlated with disease duration (R=0.57, p=0.002). Fatigue showed a clear correlation with deep breathing test (R=-0.53, p=0.004) but not with the MIBG H/M ratios.ConclusionsOur data are consistent with a multifactorial pathogenesis of fatigue and with effects of dopamine depletion in PD-related fatigue; on the other hand, our findings do not support a role for sympathetic denervation in PD-related fatigue.

Does fatigue in Parkinson's disease correlate with autonomic nervous system dysfunction?

Stocchi, Fabrizio
2018-01-01

Abstract

BackgroundDespite its negative impact on quality of life, fatigue in Parkinson's disease (PD) remains an under-recognized issue and the underlying pathology is undetermined.ObjectiveTo contribute at understanding the pathogenesis of fatigue in a naturalistic cohort of cognitively intact PD patients.MethodsIn a Caucasian population of PD patients (n=27), we evaluated to what extent fatigue (quantified as PFS-16 score) is associated with PD duration and with autonomic dysfunction, studied by both MIBG scintigraphy and autonomic nervous system testing. The latter included the head-up tilt test, Valsalva maneuver, deep breathing, and handgrip tests.ResultsPFS-16 score correlated with disease duration (R=0.57, p=0.002). Fatigue showed a clear correlation with deep breathing test (R=-0.53, p=0.004) but not with the MIBG H/M ratios.ConclusionsOur data are consistent with a multifactorial pathogenesis of fatigue and with effects of dopamine depletion in PD-related fatigue; on the other hand, our findings do not support a role for sympathetic denervation in PD-related fatigue.
2018
Autonomic nervous system
Fatigue
Myocardial scintigraphy
Parkinson’s disease
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12078/16134
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 8
social impact