Olive (Olea europaea) is one of the most widespread and economic important woody plants in the Mediterranean and Middle Eastern regions. The major phenolic compounds identified and quantified in olive and olive oil belong to three different classes: simple phenols (hydroxytyrosol (2), tyrosol); secoiridoids (oleuropein (1), the aglycone of ligstroside and their respective decarboxylated dialdehyde derivatives (3) and the lignans [(+)-1-acetoxypinoresinol & (+)- pinoresinol]. Using the physical and chemical characteristics of fatty acid esters hydroxytyrosol,1 we synthesized hydroxytyrosol oleyl nanoparticles as new drug delivery system. The nanoparticles containing drug (oleuropein, hydroxytyrosol and 3,4- DHPEA-EDA)2 were tested on neuroblastoma cells and evaluated the antioxidant proprieties.

HYDROXYTYROSOL OLEATE NANOCARRIERS FOR DELIVERY OLEUROPEIN AND DERIVATIVES ON SH-SY5Y NEUROBLASTOMA CELLS

NARDI M;
2015-01-01

Abstract

Olive (Olea europaea) is one of the most widespread and economic important woody plants in the Mediterranean and Middle Eastern regions. The major phenolic compounds identified and quantified in olive and olive oil belong to three different classes: simple phenols (hydroxytyrosol (2), tyrosol); secoiridoids (oleuropein (1), the aglycone of ligstroside and their respective decarboxylated dialdehyde derivatives (3) and the lignans [(+)-1-acetoxypinoresinol & (+)- pinoresinol]. Using the physical and chemical characteristics of fatty acid esters hydroxytyrosol,1 we synthesized hydroxytyrosol oleyl nanoparticles as new drug delivery system. The nanoparticles containing drug (oleuropein, hydroxytyrosol and 3,4- DHPEA-EDA)2 were tested on neuroblastoma cells and evaluated the antioxidant proprieties.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12078/1401
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact