Background and aim I-123-FP-CIT SPECT has been successfully used to detect the loss of dopaminergic nigrostriatal neurons in Parkinson's disease at an early stage. In this study we evaluated the capacity of I-123-FP-CIT SPECT to assess bilateral dopamine transporter (DAT) loss in de-novo hemi-Parkinson's disease (PD) patients with one-sided clinical symptoms. Patients and methods Twenty-nine de-novo hemi-PD patients at an early stage (Hoehn & Yahr stage 1) and 18 gender and age matched healthy subjects were studied. SPECT imaging was always performed at 4 h post-injection. The ratios of striatal (S) to non-specific occipital (O) binding for the entire striatum (S/O), caudate nuclei (C/O), putamina (P-put/O), and the putamen to caudate nucleus index (P-put/C) were calculated in both the basal ganglia. Results In PD patients S/O, C/O and P-put/O ratio values contralateral to the clinically affected side were significantly lower (P< 0.001) than in the control group (- 38%, - 34% and - 42%, respectively). A significant reduction (P< 0.001) of the striatal binding ratios was also found ipsilaterally (S/O, - 31%; C/O, - 28%; P-put/O, - 33%). The P-put/C index was also bilaterally significantly reduced (P< 0.01). DAT loss was significantly greater (P< 0.001) in the contralateral than in the ipsilateral S; and putamen bilaterally presented a higher dopaminergic deficit than did caudate. Conclusion Our results indicate that semi-quantitative (IFP)-I-123-CIT SPECT detects a bilateral dopaminergic deficit in early PD with unilateral symptoms and preclinical DAT loss in the ipsilateral striatal binding, corresponding to the side not yet affected by motor signs. Semi-quantitative analysis may thus be used to diagnose PD at an early stage as well as to identify individuals developing bilateral dopaminergic damage. © 2005 Lippincott Williams & Wilkins.

I-123-FP-CIT semi-quantitative SPECT detects preclinical bilateral doparninergic deficit in early Parkinson's disease with unilateral symptoms

Danieli R;
2005

Abstract

Background and aim I-123-FP-CIT SPECT has been successfully used to detect the loss of dopaminergic nigrostriatal neurons in Parkinson's disease at an early stage. In this study we evaluated the capacity of I-123-FP-CIT SPECT to assess bilateral dopamine transporter (DAT) loss in de-novo hemi-Parkinson's disease (PD) patients with one-sided clinical symptoms. Patients and methods Twenty-nine de-novo hemi-PD patients at an early stage (Hoehn & Yahr stage 1) and 18 gender and age matched healthy subjects were studied. SPECT imaging was always performed at 4 h post-injection. The ratios of striatal (S) to non-specific occipital (O) binding for the entire striatum (S/O), caudate nuclei (C/O), putamina (P-put/O), and the putamen to caudate nucleus index (P-put/C) were calculated in both the basal ganglia. Results In PD patients S/O, C/O and P-put/O ratio values contralateral to the clinically affected side were significantly lower (P< 0.001) than in the control group (- 38%, - 34% and - 42%, respectively). A significant reduction (P< 0.001) of the striatal binding ratios was also found ipsilaterally (S/O, - 31%; C/O, - 28%; P-put/O, - 33%). The P-put/C index was also bilaterally significantly reduced (P< 0.01). DAT loss was significantly greater (P< 0.001) in the contralateral than in the ipsilateral S; and putamen bilaterally presented a higher dopaminergic deficit than did caudate. Conclusion Our results indicate that semi-quantitative (IFP)-I-123-CIT SPECT detects a bilateral dopaminergic deficit in early PD with unilateral symptoms and preclinical DAT loss in the ipsilateral striatal binding, corresponding to the side not yet affected by motor signs. Semi-quantitative analysis may thus be used to diagnose PD at an early stage as well as to identify individuals developing bilateral dopaminergic damage. © 2005 Lippincott Williams & Wilkins.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12078/1178
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