1 Contributo su Rivista

1 Contributo su Rivista: [6960] Home page macrotipologia

Sfoglia

Prodotti recenti

Incommensurately modulated sodium polyiodide crystal structure discloses unconventional 1D iodine chains

Here, we report crystallographic results about gold-green crystals with metallic luster of [Na(DMSO)3]n(I2)n. XRD studies reveal that [Na(DMSO)3]n(I2)n, containing 1D iodine infinite chains is incommensurately modulated. This confutes earlier reports and potentially resolves the unclear duality about the absence/presence of bond length alternation in such chains, reported with oddities and incongruences in previously published data for several 1D iodine infinite chains, from the discovery of ...

Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis

Background: Mood disorders, including anxiety and depression, are frequently diagnosed in multiple sclerosis (MS) patients, even independently of the disabling symptoms associated with the disease. Anatomical, biochemical, and pharmacological evidence indicates that type-1 cannabinoid receptor (CB1R) is implicated in the control of emotional behavior and is modulated during inflammatory neurodegenerative diseases such as MS and experimental autoimmune encephalomyelitis (EAE). Methods: We inve...

MiR-142-3p regulates synaptopathy-driven disease progression in multiple sclerosis

Aim: We recently proposed miR-142-3p as a molecular player in inflammatory synaptopathy, a new pathogenic hallmark of multiple sclerosis (MS) and of its mouse model experimental autoimmune encephalomyelitis (EAE), that leads to neuronal loss independently of demyelination. MiR-142-3p seems to be unique among potential biomarker candidates in MS, since it is an inflammatory miRNA playing a dual role in the immune and central nervous systems. Here, we aimed to verify the impact of miR-142-3p ci...

Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis

Exercise is increasingly recommended as a supportive therapy for people with Multiple Sclerosis (pwMS). While clinical research has still not disclosed the real benefits of exercise on MS disease, animal studies suggest a substantial beneficial effect on motor disability and pathological hallmarks such as central and peripheral dysregulated immune response. The hippocampus, a core area for memory formation and learning, is a brain region involved in MS pathophysiology. Human and rodent studie...

Macrophage Plasticity and Polarization Are Altered in the Experimental Model of Multiple Sclerosis

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system. MS is characterized by infiltrations of leukocytes such as T and B lymphocytes and macrophages. Macrophages have been identified as major effectors of inflammation and demyelination in both MS and its animal model, experimental autoimmune encephalomyelitis (EAE). However, the activation and heterogeneity of macrophages in MS has been poorly investigated. Thus, in this study, we evaluated M1 and ...

Scopri

Accesso al fulltext

no fulltext6814
reserved105
open40
embargoed1

IRISanRaf